Invited Review HIGHLIGHTED TOPIC Physiology and Pathophysiology of Sleep Apnea Influence of cardiac function and failure on sleep-disordered breathing: evidence for a causative role

Caples, Sean M., Robert Wolk, and Virend K. Somers. Influence of cardiac function and failure on sleep-disordered breathing: evidence for a causative role. J Appl Physiol 99: 2433-2439, 2005; doi:10.1152/japplphysiol.00676.2005.— Heart failure is an increasingly common public health problem that is strongly linked to both central and obstructive sleep apnea, collectively referred to as sleep-disordered breathing. Much attention has been given to the deleterious effects of sleep-disordered breathing on the failing heart and potential mechanisms by which treatment of sleep-disordered breathing may result in improved cardiac performance and long-term outcomes. However, there is compelling evidence that cardiac dysfunction may contribute to sleep-disordered breathing. Although there is recognized overlap between pathophysiological mechanisms in central sleep apnea and obstructive sleep apnea, data supporting the role of cardiac function are certain forms of central sleep apnea are well established, whereas investigation into the relationship with obstructive sleep apnea is less mature but continues to evolve. This review will examine experimental and observational data that explore possible pathophysiological mechanisms and potential targets for therapy in heart failure and sleep-disordered breathing.